I am a strong believer in performing both AHG and enzyme panels together in routine antibody workups. I especially feel this is important when the patient is R1R1 since I always want to rule out anti-c. Sometimes, anti-c is only identified in the enzyme phase.
This is a case from my files of an R1R1 patient with the following results:
Enzyme Panel (Ficin):
This anti-S is enzyme-labile but anti-c is revealed, only reacting at enzyme phase. The patient was Kell-negative so I selected S-negative, R1R1 K-negative RBCs for transfusion. Anti-c can be a dangerous antibody causing severe hemolytic disease of the fetus/newborn and sever hemolytic transfusion reaction. If only the AHG panel had been performed, the anti-c would have been missed.