Processing and Software Building 39: Atreus and Reveos

Automated component processing is an almost hands-free separation of into packed RBCs (ready for leukodepletion), buffy coat platelets (ready for pooling), leukodepleted plasma, and a residual buffy coat.  The older Atreus device takes about 10 minutes for one whole blood unit whereas the newer Reveos device needs slightly more than 20 minutes to process four whole blood units.  At the end of processing:

  1. RBCs are ready for leukodepletion using the integral filter provided with the kit.
  2. Plasma is ready for pathogen-inactivation and freezing.
  3. Buffy coat platelets are ready for pooling using the Platelet Yield Index PYI.
    1. Further processing (filtration and Mirasol treatment) occurs if the donor marker testing results pass
  4. Residual buffy coat is not a clinical product but may be used for quality control for stem cell processing and/or cell line expansion

The process in Medinfo is as follows:

  1. Receive the whole blood units for processing by reading the ISBT specimen barcode.
  2. Collection data (volume, time to complete collection, time of collection, etc.) is transferred to the component processor.
  3. Select the processing machine:  Atreus vs. Reveos
  4. Select the protocol:  2C (RBCs and plasma) versus 3C (RBCs, platelets, and plasma)
  5. Further processing as per the flow diagrams.

At HMC Doha, Medinfo developed the first bidirectional interfaces to both Reveos and Atreus.

To Be Continued

2/9/20